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KMID : 0367419690100030043
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Journal of Korean Pediatric Society
1969 Volume.10 No. 3 p.43 ~ p.46
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Acute Accidental Isoniazid Poisoning
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孫基勇/Sohn, Ki Yong
鄭英桓/金顯宇/李美那/李謹洙/Chung, Young Hwan/Kim, Hyun Woo/Lee, Mi Na/Lee, Keun Soo
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Abstract
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With the common use of isoniazid, the problem of accidental poisoning is inevitable in Korea. Only five cases of acute isoniazid poisoning were reported in the English literature until 1963. Since the opening of the National Medical Center in 1958, we have experienced two accidental cases of acute poisoning from an overdofe of isoniazid in children.
Case 1, a 33-month-old girl, ingested approximately 1,000 mg of isoniazid and developed irritability, flushing, sweating and high fever one and a half hour later; following by vomiting and convulsions. She was successfully given anti-convulsive drugs and pyridoxine as well as symptomatic treatment.
Case 2, a 26-month-old boys, was estimated to have ingested 1,200 mg isoniazid and had convulsions two hours later. The patient was treated with pyridoxine and symptomatically. He recovered, but an electroencophalogram after sedative drugs on the eighth hospital day was interpreted as being "slightly abnormal". Abnormal physical findings were not detectable when the patient was seen at the out-patient department one month later.
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